Fresh analysis indicates that patients who stop using popular slimming jabs like Mounjaro or Wegovy can put back on reduced body mass much more quickly than those who halt conventional diet and exercise regimens.
Published data in a leading medical journal demonstrates that while obese people can lose about a fifth of their total mass while using the jabs, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals buying such drugs should be informed of the danger of fast rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
That rate of recovery suggests a reversion to starting mass in about a year and a half.
Comparing Therapies
The study, which reviewed 37 of trials involving thousands of participants, contrasted the effects of the injectable medications with other pills.
Scientists note that people who lose weight through lifestyle changes alone usually experience a less rapid creep back—around 0.1 kg a month—after stopping.
Understanding the Fast Rebound
Experts believe the way of the injections accounts for the accelerated weight return.
These medications imitate a natural hormone called GLP-1, which controls appetite.
"Sustained high doses of GLP-1 concentrations several times higher than normal may cause the body to produce less of its endogenous GLP-1, and could lessen sensitivity to its actions," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication results in appetite is no longer kept in check, making overeating far more likely."
An Ongoing Condition?
Health authorities suggest the injections for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians contend that, considering the high risk of relapse, the therapy is often long-term.
This view is echoed by pharmaceutical companies, who say that the results "emphasize the persistent character of excess weight," comparing it to managing diseases like high blood pressure.
User Testimonies
People who have stopped the jabs explain a intense resurgence of appetite.
"I experienced a switch activating and you become ravenous," described one woman.
The struggle is exacerbated if users have not developed permanent dietary or behavioural changes during treatment.
Significant Adoption
Survey data show that millions of adults in the UK have used these injections in the last 12 months, with demand being substantial.
- Adoption is higher among females than males.
- The middle-aged age group shows the greatest level of interest.
- A large proportion access the drugs through private prescriptions rather than the NHS.
Ultimately, researchers stress that while these medications are effective agents for shedding pounds, they are not a permanent fix and lasting health benefits hinges on integrated lifestyle management.
